https://www.theknottlab.org/publications daily 0.75 2023-05-30 https://www.theknottlab.org/research daily 0.75 2022-01-01 https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/1615633168013-UHNY5WFCFNQUW6F70WFN/Untitled+%284%29.png Research Bacterial viral RNA sensors - Images adapted from IGI Glossary Icon Collection. https://www.theknottlab.org/contact daily 0.75 2022-05-28 https://www.theknottlab.org/home daily 0.75 2023-01-16 https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/1615633112942-FPU3FTX1TQGA8W7O1Y4P/Untitled+%284%29.png Home Created with BioRender.com. https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/1615523300892-B0QJW5S4ARHYJLF6H9QE/3Asset+2.png Home https://www.theknottlab.org/news daily 0.75 2023-02-02 https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/ee621f9c-da86-4870-a282-4b98506945e5/pic_cyntia.jpg News https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/1615523498583-KLRLL4684BEU3QPUV25J/IMG_2881.jpeg News https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/f093eb6c-ce8d-40f8-997b-623686fe7c27/Jenni_headshot.jpg News https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/1634798638212-23194R96OP4R04DLEK46/PXL_20211014_005237424_SparkVideo-2.gif News https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/1634799066043-B3C6M4A38EJWYZM0P31Y/AKTA.jpeg News https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/c00ec45d-1a93-470e-8ad5-e227163f05b4/Image+from+iOS+%281%29.jpg News https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/d49c9f17-9597-4ff9-b28a-2d3ba82a94dc/PXL_20211215_064522381.jpg News https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/c226efc3-3aa5-48ec-97ff-5fa2ee902ab0/Giovanni_Leandri.jpeg News https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/e5fde5ed-e48c-487a-ba94-3e2a7caf5474/PXL_20220514_065044127.jpg News https://www.theknottlab.org/structures daily 0.75 2022-01-05 https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/0d811e54-227b-4557-9482-ff7baf9159f5/5W1H.png Structures L. bacterium CRISPR-Cas13a (5W1H). https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/8782f023-82f9-48e0-8d1c-f2ca1372a834/6VPC.png Structures - Make it stand out S. pyogenes CRISPR-Cas9 base editor ABE8e (6VPC). https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/fc74fc96-92e6-4981-82f2-50ec4d0a5b69/6P7M.png Structures L. bacterium CRISPR-Cas12a bound to AcrVA4 (6P7M). https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/9a4384e6-b052-4835-9662-70f4553d334f/6P7N.png Structures - Make it stand out L. bacterium CRISPR-Cas12a bound to dimeric AcrVA4 (6P7N). https://www.theknottlab.org/funding daily 0.75 2024-02-02 https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/e74bcbd2-9861-468c-a1fe-312394c8eb6d/arclogo_pcinline.jpg https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/3cfc0ef5-2f06-4e3b-a9f7-23f1c0bc6b4c/WebsiteLogo-1.png https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/250fcd14-2991-4e0f-8dbe-943267bc9787/Unknown-2.png https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/da858c3c-f380-4051-8f85-12e8e9fa9fb7/SM-Snow-Medical-logo-RGB-scaled.jpeg https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/97c4200b-cf8e-4408-a7be-7f9c9530126e/Screenshot+2024-02-02+at+3.30.39%E2%80%AFpm.png https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/4575b4e9-5a79-45a0-b04f-797161ce5cc0/NHMRC.jpg https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/05340c49-38f0-4b40-b8ed-0863dd956373/Monash-BDI-logo-print-300dpi-SMC-18012016.jpg https://www.theknottlab.org/our-team daily 0.75 2023-02-02 https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/67e21a1e-a0de-4b65-afb6-c5f94b9c88c3/IMG_20220228_141956.jpg Our Team - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/028d475a-3c13-4886-97cc-5384bb3cd863/pic_cyntia.jpg Our Team - Cyntia Taveneau Cyntia is a Research Fellow and cryo-electron microscopist in the Knott Lab. Cyntia is using her structural biology skillset to solve critical questions about the evolution of CRISPR-Cas and how we can better engineer CRISPR systems for applications. https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/7168af07-e2f2-432a-a295-96021070e649/DSC06895.jpg Our Team - Nathan Chai Nathan is a Research Scientist in the Knott Lab interested in applying CRISPR-Cas enzymes to solve real world problems. He is driving a project that looks to establish CRISPR point of care diagnostics for use in remote Australian communities in collaboration with Griffith University. https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/c24480db-43f7-483f-9ef5-a15b89dadadf/IMG_20220209_085842836_HDR.jpg Our Team - Emily To Emily is an Honours student continuing on from a summer research project to study a novel family of bacterial immune systems that protect against phage infection. https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/1615420512689-DUPN8KHRM6F515ZA3C51/Untitled.png Our Team - Interested in RNA, host pathogen interactions, or biotechnology? Join us at Monash University! https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/214739f2-8055-4212-b6ad-cfe5aa0672fa/Jenni_headshot.jpg Our Team - Jenni Hayward Jenni is a Research Fellow and biochemist in the Knott Lab. Jenni has started a project using high-throughput biochemistry to examine the activity of lots of novel enzymes in parallel. Her work will uncover new ways to synthesize or modify RNA for biotechnology. https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/65ac64a0-21cf-49d5-a698-f226231a1905/PXL_20211210_065015507_2.jpg Our Team - Roland Calvert Roland is a Ph.D. student in the Department of Biochemistry and Molecular Biology. After completing his Honours in the Knott Lab he is now pursuing a PhD to research how CRISPR-Cas enzymes specifically select and cut RNA. His work will provide key insights into catalysis to accelerate biotech applications. https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/4ea900fa-1d45-428e-a844-70c4cd49b702/SM_Clayton_0076__MP_8032+copy.jpg Our Team - Gavin Knott Gavin earned his Ph.D. from the University of Western Australia where he studied under Prof. Charlie Bond and Prof. Archa Fox. In 2016 he moved to the University of California Berkeley as a postdoctoral fellow under the supervision of Prof. Jennifer Doudna. He started his own independent research group at Monash University in 2021. Gavin is passionate about RNA, molecular evolution, and training the next generation of innovative scientists. https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/69299adf-e2ef-42e6-8103-cf0e18eedb27/9003ab1a-3dbd-41e3-af7d-9e8f043763c6.jpg Our Team - Manisha Treeby Manisha is a Research Fellow in the Knott Lab with extensive experience in molecular biology and biochemistry. Manisha is working to reveal how CRISPR enzymes have evolved to have drastically different biophysical properties. Her work sets the stage to better engineer CRISPR enzymes for RNA detection and diagnostics applications. https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/cbe854b4-0b8c-40f1-b525-2fd705c50e86/Giovanni_Leandri.jpeg Our Team - Giovanni Leandri Giovanni is a Ph.D. student in the Knott Lab studying novel bacterial defence systems. He is using a combination of bioinformatics, microbiology, and structural biology to describe their function and reveal their potential as tools for biotechnology. https://images.squarespace-cdn.com/content/v1/6035da478a4f69097bf0ca88/6afecebc-ce62-46c9-a53b-21a90f7ed262/Loki+Website+Image1.jpg Our Team - Loki Sangalli Loki is a Ph.D. student in the Knott Lab building on his Honours and summer research project to develop precise RNA targeting systems. 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