Publications

2026

Janik Clement, Tim Lkhagvajargal, Brad L Hoare, Tiffany Myint, Daniel R Fox, Chunxiao Wang, Gavin J Knott, Ross AD Bathgate, and Rhys Grinter (2026). A complete RXFP1-relaxin interaction model unlocks the design of potent mini-protein modulators. bioRxiv.
Fabian Munder, Matthew D Johnson, Imogen Samuels, Laura McCaughey, Oleksii Zdorevskyi, Chunxiao Wang, Ashleigh Kropp, Lauren Zavan, Erin P Price, Derek S Sarovich, Swati Varshney, Christopher A McDevitt, Hari Venugopal, Vivek Sharma, Matthew T Doyle, Francesca Short, Debnath Ghosal, James PR Connolly, Gavin J Knott, and Rhys Grinter (2026). L-type pyocins inhibit the BAM complex to kill without cell entry. Nature Communications.
Jie-Ning Chuang, Jacob Purcell, Loki Sangalli, Joseph Rosenbluh, Gavin J Knott, Simon Corrie, and Gil Garnier (2026). Dissecting the disconnect between circuit activation and dominant adaptive evolution in cytoplasmic phage-assisted continuous evolution (PACE) of an EGFR nanobody. Frontiers in Bioengineering and Biotechnology. 14.
Jacob Purcell, Ling Liu, Roland W Calvert, Brooke K Hayes, Cheng Huang, Chen Davidovich, Gavin J Knott, and Joseph Rosenbluh (2026). DUSP11 is an RNA triphosphatase that limits PspCas13b activity by destabilizing gRNA abundance in mammalian cells. Nucleic Acids Research. 54 (8) gkag412.
Sungmin Son, Amy Lyden, Carlos F Ng, Andres Dextre, Jeffrey Shu, Stephanie I Stephens, Parinaz Fozouni, Gavin J Knott, Dylan CJ Smock, Tina Y Liu, Daniela Boehm, Camille Simoneau, G Renuka Kumar, Jennifer A Doudna, Melanie Ott, and Daniel A Fletcher (2026). Programmable kinetic barcoding for multiplexed RNA detection with Cas13a. Nature Biomedical Engineering. 1-12.
Cyntia Taveneau, Her Xiang Chai, Jovita D’Silva, Rebecca S Bamert, Honglin Chen, Brooke K Hayes, Roland W Calvert, Jacob Purcell, Daniel J Curwen, Fabian Munder, Lisandra L Martin, Jeremy J Barr, Joseph Rosenbluh, Mohamed Fareh, Rhys Grinter, and Gavin J Knott (2026). De novo design of potent CRISPR–Cas13 inhibitors. Nature Chemical Biology. 22, 1342–1350.

2025

2024

Tricia L Lo, Qi Wang, Joshua Nickson, Bryce JW van Denderen, Deanna Deveson Lucas, Her Xiang Chai, Gavin J Knott, Harshini Weerasinghe, and Ana Traven (2024). The C-terminal protein interaction domain of the chromatin reader Yaf9 is critical for pathogenesis of Candida albicans. Msphere. 9 (3) e00696-23.

2023

2022

2021

2020

Pausch, P., Al-Shayeb, B., Bisom-Rapp, E., Tsuchida, CA., Li, Z., Cress, BF., Knott, GJ., Jacobsen, SE., Banfield, JF., and Doudna, JA. (2020) CRISPR-CasΦ from huge phages is a hypercompact genome editor. Science. 369, 333-337.

Dai, J., Knott, GJ., Fu, W., Lin, TW., Furst, AL., Britt, D., and Francis MB. (2020) Protein-embedded metalloporphyrin arrays templated by circularly permuted tobacco mosaic virus coat proteins. ACS Nano. 15, 5, 8110-8119.

2019

2018

2017

James, AM., Jayasena, AS., Zhang, J., Berkowitz, O., Secco, D., Knott, GJ., Whelan, J., Bond, CS., and Mylne, JS. (2017) Evidence for ancient origins of Bowman-Brik inhibitors from Selaginella moellendorffii. The Plant Cell. 29, 461-473.

2016

2015

2014

Middleton, CL., Parker, JL., Knott, GJ., White, MF., and Bond, CS. (2014) Crystal ‘unengineering’: reducing the crystallisability of Sulfolobus solfataricus Hjc. Aus. Journal of Chemistry. 67. 1818-1823.